Reviews of Environmental Contamination and Toxicology 191

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President Gee highlighted the group's work and noted recent NIH awards to Drs. A detailed study of the molecular aspects of nerve transmission will be covered with special emphasis on the uptake, storage, release, biosynthesis, and metabolism of specific neurotransmitters. Consequently, the heat shock proteins are also referred to as stress proteins and their upregulation is part of the stress response. Examples of appropriate study areas for this FOA include but are not limited to: Analysis and comparison of cell, tissue, organ-specific effects of drug responses across various developmental stages. e.g., changes in receptor coupling second messengers, and signal transduction pathways; Use of sensitive, specific rapid methods (e.g., microarray or proteomic) to identify predictive biomarkers of drug response and toxicity in children; Application of systems toxicology to developmental toxicology studies that can lead to the development of predictive of toxicity biomarkers and a better understanding of the mode of action of drugs and xenobiotics; Inducibility and imprinting of genes involved in pharmacokinetics or pharmacodynamics; Regulation and ontogenetic expression of DMEs, transporters, receptors, and related proteins including mechanisms involved, impact of disease processes, and the roles of endogenous and exogenous modulators.

Pages: 222

Publisher: Springer; 2007 edition (July 27, 2007)

ISBN: 0387691626

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