By Robert Lev
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features consolidates the colossal physique of simple technological know-how and medical information linked to adenomatous polyps of the colon, a lot of it encouraged by means of the belief that the majority colorectal carcinomas appear to come up in such polyps. This ebook strives to guage those info, with specific emphasis on their implications for administration of polyp-bearing topics. issues comprehensively explored comprise anatomy and histology of the conventional colon; pathologic features of adenomatous polyps, differential analysis, and grading schemes for measure of dysplasia and villosity; adenomatous polyposes; histologic and epidemiologic proof for the malignant capability of adenomatous polyps; and detection and administration, with unique realization to endoscopy, endoscopic polypectomy, the malignant polyp, and post-polypectomy surveillance schedules.
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Additional resources for Adenomatous Polyps of the Colon: Pathobiological and Clinical Features
Figiel LS, Figiel SJ, Wietersen FK (1965) Roentgenologic observations of growth rates of colonic polyps and carcinoma. Acta Radiol [Diagn] (Stockh) 3:417-429. Filipe MI (1969) Value of histochemical reactions for mucosubstances in the diagnosis of certain pathological conditions of the colon and rectum. Gut 10:577-586. Forster SJ, Talbot IC, Clayton DG, Critchley DR (1986) Tumor basement membrane laminin in adenocarcinoma of rectum: An immunohistochemical study of biological and clinical significance.
18 . Hyperplastic polyp. Lumen on right. The upper crypts are dilated and show infoldings of eosinophilic cytoplasm with scattered goblet cells. Deep crypts on left are more basophilic and contain fewer goblet cells than normal. H&E; X 176, reproduced at 53%. 18) . , 1974), the cells at each level of the crypt are hypermature, resembling those found at higher levels in normal crypts. , 1974) show that the cells in the lower halves of the crypts normally incorporate tritiated thymidine but migrate more slowly upward than normal cells; superficial epithelium, like the normal , fails to incorporate isotope.
These represent reactive changes in the mildly dysplastic epithelium shown in more classic form in subjacent areas, rather than a higher grade of dysplasia. H&E; x282 , reproduced at 55%. Microscopic Features 17 FIGURE 2. 16. Squamous metaplasia in adenomatous polyp. The metaplastic cell clusters contain abundant pale eosinophilic cytoplasm. H&E; x 176, reproduced at 55%. a. Problems in Grading Dysplasia In most polyps, varying degrees of dysplasia can be found. Both Kozuka (1975) and Konishi and Morson (1982) believe that the assigned grade should reflect the most dysplastic changes even though these may be quantitatively insignificant.