By Blanca Hernández-Ledesma, Miguel Herrero
A part of the IFT Press sequence, this e-book studies the myriad released details on bioactive elements derived from marine meals, allowing researchers and product builders to choose acceptable sensible materials for brand new products.
Chapters conceal meals and nutrients constituents from either animal and plant marine resources, concentrating on these which exhibit organic houses and whose constituent compounds were remoted and pointed out as most likely lively. This ebook additional addresses the organic actions of PUFAs (Polyunsaturated fatty acids), oils, phospholipids, proteins and peptides, fibres, carbohydrates, chitosans, nutrients, fucoxantin, polyphenols, phytosterols, taurine, among others. those elements, present in quite a few marine-derived meals, were confirmed to have preventative homes with reference to high blood pressure, oxidative rigidity, irritation, cardiovascular ailments, melanoma and different human diseases.
Extraction equipment and research recommendations also are addressed. meant for foodstuff scientists, foodstuff technologists and nutrition engineers in academia, and govt, this book reviews the great volume of present examine during this fast-moving and commercially invaluable area of meals and foodstuff science.
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Extra info for Bioactive Compounds from Marine Foods: Plant and Animal Sources
Significant cytotoxicity (50% lethal concentration (LC50 ) Ͻ 23 nM) has been observed for NCI-H460 human lung tumor cells and mouse neuro-2a cells. The therapeutic profile of coibamide A is inspirational from the perspective of further biomedical investigation. Also promising is the extensive N-methylation present in 35, which may benefit from improved pharmacological properties and drugability as compared to standard peptides (Morishita & Peppas 2006). 5 Polyketide–peptide The cyclic hexapeptide paltolide A (36) was isolated from a deepwater specimen of the marine sponge Theonella swinhoei, from Palau, by Plaza et al.
1983). A significant finding was reported in 1997, when 12 was shown to effectively interfere with Saccharomyces cerevisiae actin cytoskeleton in under 5 minutes (Ayscough et al. 1997). 6 Histogram of peer-reviewed publications on latrunculin A (12), salinosporamide A (6), and largazole (23) classes of marine-derived natural products, from the year of isolation to 2011 (data based on search of SciFinder® ). ) JWST362-c01 JWST362-Hernandez September 9, 2013 12:53 Printer Name: Trim: 244mm × 170mm An Update on the Biomedical Prospects 21 this same time, latrunculin A became commercially available as a chemical probe, which has since contributed to the upward trend in the number of peer-reviewed publications surrounding it.
2009a) Ammosamides A and B target myosin. Angewandte Chemie, International Edition 48, 728–732. Hughes, C. , MacMillan, J. , Gaudˆencio, S. , Jensen, P. R. & Fenical, W. (2009b) The ammosamides: structures of cell cycle modulators from a marine-derived Streptomyces species. Angewandte Chemie, International Edition 48, 725–727. Hughes, C. , Yang, Y. , Liu, W. , Dorrestein, P. , La Clair, J. J. & Fenical, W. (2009c) Marinopyrrole A target elucidation by acyl dye transfer. Journal of the American Chemical Society 131, 12 094– 12096.