Download Chronic Hepatitis B and C : Basic Science to Clinical by Chiaho Shih PDF

By Chiaho Shih

The scope of the ebook is especially large, overlaying quite a lot of parts in HBV/HDV and HCV learn, together with either simple and medical technology. the chosen themes variety from epidemiology, immunology, molecular virology and oncology, to medical treatment.

Chronic Hepatitis B and C comprises 14 chapters, each one being a evaluation of a distinct subject on HBV or HCV. whereas overview articles on a different subject are available in periodical journals, they have a tendency to be extra limited in presentation. hence, this booklet will supply extra in-depth insurance of what are awarded as "unpublished effects" and "data now not proven" in magazine articles. moreover, numerous authors during this publication don't write evaluate articles frequently. a few authors wrote experiences on a particular subject on a regular basis, yet they attempted a brand new subject during this booklet (e.g., Dr. YF Liaw on average course," Dr. Shih on "virion release," Dr. Michael Lai on "lymphotropism of HCV," and so forth ... ). total, the ebook will supply invaluable info on the slicing age.

Readership: Researchers in virology, infectious ailments and melanoma medicine.

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Additional resources for Chronic Hepatitis B and C : Basic Science to Clinical Applications

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62. Chu CM, Liaw YF. (2007) Spontaneous relapse of hepatitis in inactive HBsAg carrier. Hepatol Int 1: 311–315. 63. de Franchis R, Meucci G, Vecchi M, et al. (1993) The natural history of asymptomatic hepatitis B surface antigen carriers. Ann Intern Med 1: 118: 191–194. 64. Zacharakis GH, Koskinas J, Kotsiou S, et al. (2005) Natural history of chronic HBV infection: a cohort study with up to 12 years follow-up in North Greece (part of the Interreg I-II/EC-project). J Med Virol 77: 173–179. 65. Papatheodoridis GV, Chrysanthos N, Hadziyannis E, et al.

However, the presence of HBsAg and HBeAg in the serum of chronic patients may mask the ability to detect circulating antibodies and may obscure the onset of seroconversion. The available commercial assays usually detect anti-HBs and anti-HBe antibodies only after the antigens have been cleared from the serum. 23 All patients were seronegative for antibodies specific for the envelope antigens or the HBeAg when the current commercial assays were utilized. In contrast, virtually all chronically infected patients with liver disease, and approximately 50% of chronic patients without liver disease, demonstrated anti-HBe and anti-envelope antibodies when sera were tested in the more sensitive immunoassays.

39 These findings suggest that HBeAg seroconversion usually occurs between 15 and 40 years of age in perinatally acquired chronic HBV infection. 37 HBeAg Persistence and Its Outcome In some patients, the immune clearance phase may last for many years without HBeAg seroconversion during a long-term follow-up. 37,40 Clinical studies also show that persistence of serum HBeAg is associated with an increased risk for progression to cirrhosis, HCC development and liver related mortality. 43 These findings indicate that prolonged HBeAg positive phase is associated with an increased risk of disease progression.

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