Download Complement and Kidney Disease by Peter F Zipfel PDF

By Peter F Zipfel

The certainty how supplement pertains to glomerular ailments has developed significantly over the last years. huge proof has gathered that specify how a faulty or deregulated supplement procedure leads to kidney illnesses. The blend and shut interplay of simple examine with scientific medication has confirmed an enormous function of supplement effector and regulatory proteins in pathological settings of the kidney. a wide panel of specific human kidney illnesses reminiscent of hemolytic uremic syndrome (HUS), membrano proliferative glomerulonephritis (MPGN), systemic lupus erythematosus (SLE) and in ischemic reperfusions harm and transplantation are as a result of faulty supplement keep watch over. Genetic analyses have pointed out mutations in supplement regulators which are linked to those illnesses. Mutations were pointed out within the fluid section replacement pathway regulator issue H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The useful characterization of the mutant proteins permits to outline the pathophysiological occasions on a molecular point. those new innovations and information on affliction mechanisms already allowed to set up new diagnostic and novel promising healing methods for numerous human kidney illnesses.

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It thus appears that extravascular production of complement is sufficient for activation of the complement cascade. Gene expression studies on human kidney biopsy material revealed that expression of C3 and C4 mRNA is markedly up-regulated in a variety of inflammatory conditions [74–76]. This is especially so in rejecting kidney allografts [76]. Using an ELISA that is specific for the donor C3, Tang et al. [77] found that a single donor kidney contributes 4–5% of the total circulating C3, which increases during allograft rejection.

J Am Soc Nephrol 11: 2395–2403 Montinaro V, Lopez A, Monno R, Cappiello V, Manno C, Gesualdo L, Schena FP (2000) Renal C3 synthesis in idiopathic membranous nephropathy: correlation to urinary C5b-9 excretion. Kidney Int 57: 137–146 Newman DJ, Thakkar H, Gallagher H (2000) Progressive renal disease: does the quality of the proteinuria matter or only the quantity? Clin Chim Acta 297: 43–54 Tang S, Lai KN, Sacks SH (2002) Role of complement in tubulointerstitial injury from proteinuria. Kidney Blood Press Res 25: 120–126 Van Kooten C, Langers AM, Bruijn JA, Daha MR (1999) Role of tubular cells in progressive renal disease.

Examples of this kind of damage include post-infectious nephritis, anti-glomerular basement membrane (GBM) nephritis and certain forms of lupus nephritis. The third site of immune complex deposition is the mesangium. It is accessible without crossing the GBM. Immune complex deposition at this site can lead to mesangial proliferation and occasionally to extracapillary proliferation. Complement and Kidney Disease, edited by Peter F. Zipfel © 2006 Birkhäuser Verlag Basel/Switzerland 37 Stefan P. Berger et al.

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