Download Diet-Microbe Interactions in the Gut: Effects on Human by Kieran Tuohy, Daniele Del Rio PDF

By Kieran Tuohy, Daniele Del Rio

Drawing on specialist evaluations from the fields of food, intestine microbiology, mammalian body structure, and immunology, Diet-Microbe Interactions for Human Health investigates the facts for a unified illness mechanism operating throughout the intestine and its resident microbiota, and linking many inflammation-related persistent nutrition linked illnesses. state-of-the-art post-genomic stories can spotlight the $64000 function performed by means of our resident intestinal microbiota in settling on human future health and affliction. Many continual human ailments linked to glossy existence and diets - together with these localized to the intestinal tract like inflammatory bowel disorder and celiac ailment, and extra pervasive systemic stipulations equivalent to weight problems, diabetes and heart problems - are characterised through aberrant profiles of intestine micro organism or their metabolites. lots of those ailments have an inflammatory foundation, frequently featuring with a prolonged low-grade systemic irritation, hinting at continual and irrelevant activation of inflammatory pathways. during the presentation and research of contemporary food stories, this ebook discusses the potential mechanisms underpinning the illness strategies linked to those pathologies, with excessive fats diets showing to predispose to illness, and biologically lively plant elements, customarily fiber and polyphenols, showing to lessen the danger of power sickness development.

  • One accomplished, translational resource for all facets of food and diet's impact on gastrointestinal well-being and disease
  • Experts in meals, vitamin, microbiology and immunology take readers from the bench examine (cellular and biochemical mechanisms of supplementations and food) to new preventive and healing approaches
  • Clear shows via top researchers of the mobile mechanisms underlying nutrition, immune reaction, and gastrointestinal ailment aid training nutritionists and clinicians (gastroenterologists, endocrinologists) map out new parts for scientific examine and structuring scientific recommendations

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Diet-Microbe Interactions in the Gut: Effects on Human Health and Disease

Drawing on specialist critiques from the fields of food, intestine microbiology, mammalian body structure, and immunology, Diet-Microbe Interactions for Human healthiness investigates the proof for a unified affliction mechanism operating throughout the intestine and its resident microbiota, and linking many inflammation-related continual nutrition linked illnesses.

Extra resources for Diet-Microbe Interactions in the Gut: Effects on Human Health and Disease

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The species we described until the year 2000 were also the most easily cultivated, and given the special attention of funding agencies towards pathogens, we fundamentally ignored the genome to function relation for the vast majority of our commensal organisms which do not cause disease and a handful of bacterial species used in food production and shown to dominate the gut microbiota of breast-fed infants, the lactobacilli and bifidobacteria, respectively. Furthermore, for a century the study of microorganisms has been limited by the ability to cultivate them.

Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature. 2006;444:1022À1023. 41. Turnbaugh PJ, Ley RE, Mahowald MA, et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444:1027À1031. 42. Dumas ME, Barton RH, Toye A, et al. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulinresistant mice. Proc Natl Acad Sci USA. 2006;103:12511À12516. 43. Holmes E, Loo RL, Stamler J, et al.

Falush D, Wirth T, Linz B, et al. Traces of human migrations in Helicobacter pylori populations. Science. 2003;299:1582À1585. 33. De Filippo C, Cavalieri D, Di Paola M, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA. 2010;107:14691À14696. 34. Wu GD, Chen J, Hoffmann C, et al. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011;334:105À108. 35. Tuohy K, Davies M, Rumsby P, Rumney C, Adams MR, Rowland IR.

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