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By Cook

'Key scientific issues in severe Care' bargains an integral and useful consultant for examination revision and medical perform. Written and edited via experts with a wealth of scientific adventure, this publication presents swift entry to middle themes in serious care. every one subject is written in a concise and easy-to-digest structure, making this publication the fundamental source for examination revision and quickly reference on the aspect of care.

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Further reading Benger J, Nolan J, Clancy M. Emergency airway management. New York: Cambridge University Press, 2008. Cook TM, Woodall N, Harper J, Benger J. Major complications of airway management in the UK: results of the Fourth National Audit Project of the Royal College of Anaesthetists and the Difficult Airway Society. Part 2: intensive care and emergency departments. Br J Anaesth 2011; 106:632–642. Intensive Care Society. Standards for Capnography in Critical Care. London: Intensive Care Society, 2009.

Each 10-fold dilution increases the pH by 1 unit. Buffers An acid–base buffer is a solution of two or more chemical compounds that prevents marked changes in H+ concentration when an acid or a base is added. The pK of a buffer system defines the pH at which the ionised and unionised forms are in equilibrium. It is also the pH at which the buffer system is most efficient. Important buffer systems are found in plasma and cells (including red blood cells). The Henderson Hasselbalch equation considers the relationship of a buffer system to pH.

Conventional amphotericin B causes reactions related directly to the infusion and is nephrotoxic. Lipid-based formulations enable higher doses to be used. Liposomal amphotericin B has fewest toxic effects, and is most widely used. 2. g. fluconazole and itraconazole): These inhibit the fungal enzyme lanosterol demethylase, which synthesizes ergosterol, and thereby disrupts cell membrane synthesis. Fluconazole is active against Candida albicans as well as other fungi, but not Candida glabrata or Aspergillus spp.

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