Download Liver Disease in Children by Frederick J. Suchy, Ronald J. Sokol, William F. Balistreri PDF

By Frederick J. Suchy, Ronald J. Sokol, William F. Balistreri

Thoroughly revised re-creation of the best reference on pediatric liver affliction. Liver ailment in little ones, third variation offers authoritative insurance of each element of liver affliction affecting babies, young children, and kids. Chapters are written by way of foreign specialists and tackle the original pathophysiology, manifestations, and administration of those issues within the pediatric inhabitants. The 3rd variation has been completely up to date and contours new contributions on liver improvement, cholestatic and autoimmune problems, fatty liver disorder, and inborn error of metabolism. a vital source for all physicians interested by the care of youngsters with liver affliction.

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Control of pancreas and liver gene expression by HNF transcription factors. Science 2004;303:1378–81. Chen WS, Manova K, Weinstein DC, et al. Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev 1994;8:2466–77. Duncan SA, Manova K, Chen WS, et al. Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst.

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Development 1993;118:47–59. Kaestner KH, Katz J, Liu Y, et al. (1999). Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo. Genes Dev 1999;13:495–504. Shih DQ, Navas MA, Kuwajima S, et al. Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3alpha-deficient mice. Proc Natl Acad Sci U S A 1999;96: 10152–7. Ang S-L, Rossant J. HNF-3b is essential for node and notochord formation in mouse development.

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