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Extra resources for Nature (Vol. 433, No. 7022, 13 January 2005)

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The most likely wind speeds during the Marinoan deglaciation can be estimated by making use of wave energy spectra or co-cumulative power spectra40. Within the range of hindcast wave period (21–30 s), co-cumulative power spectra become asymptotic at greater than ,20 m s21, indicating the upper cutoff for waves contributing to the energy distribution (Fig. 4b). Using energy spectra data, the maximum contribution to the energy spectrum at 20 m s21 wind speed is T ¼ 14–20 s (Fig. 4a). Consequently, the Marinoan wave periods can be regarded as exceptional.

Karplus, M. Native proteins are surface-molten solids: Application of the 132 Lindemann criterion for the solid versus liquid state. J. Mol. Biol. 285, 1371–1375 (1999). 25. DePristo, M. , de Bakker, P. I. & Blundell, T. L. Heterogeneity and inaccuracy in protein structures solved by X-ray crystallography. Structure 12, 831–838 (2004). 26. Hoch, J. , Dobson, C. M. & Karplus, M. Vicinal coupling constants and protein dynamics. Biochemistry 24, 3831–3841 (1984). 27. Best, R. , Clarke, J. & Karplus, M.

USA 97, 2064–2068 (2000). 18. Scheek, R. , Torda, A. , Kemmink, J. & van Gunsteren, W. F. in Computational Aspects of the Study of Biological Macromolecules by Nuclear Magnetic Resonance Spectroscopy (eds Hoch, J. , Redfield, C. & Poulsen, F. ) 209–217 (Plenum, New York, 1991). 19. Bonvin, A. M. J. , Rullmann, J. A. , Lamerichs, R. M. J. , Boelens, R. & Kaptein, R. ‘Ensemble’ iterative relaxation matrix approach: A new NMR refinement protocol applied to the solution structure of crambin. Proteins 15, 385–400 (1993).

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